Jaargang 9, Abstractboek DHC, Maart 2012

Jaargang 9, Abstractboek DHC, Maart 2012



A Good Manufacturing Practice procedure to generate therapeutic numbers of highly pure anti-leukemic virus-specific T-cells

The Aryl hydrocarbon Receptor antagonist StemRegenin1 promotes expansion of immature hematopoietic progenitors

Generation of allo-HLA restricted T-cells with potent B-cell reactivity using MHC tetramer pull down carries the risk of off-target reactivity

Pre-clinical evaluation of -generated natural killer cells as immunotherapeutic product against acute myeloid leukemia

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Developing thymic regenerative therapy by generating thymic epithelial precursor cells from induced pluripotent stem cells

Towards immunotherapy of acute myeloid leukemia with allogeneic NK cells generated from umbilical cord blood hematopoietic progenitor cells

miR34-a and FOXP1 are involved in a negative feedback loop responding to double-stranded DNA breaks in developing B cells

Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma

Persistent fatigue among (long-term) non-Hodgkin lymphoma survivors: results from the longitudinal population-based PROFILES registry in the South of the Netherlands

Optimal treatment sequencing in patients with multiple myeloma not eligible for stem cell transplantation: modelling as a solution to questions that trials can’t answer?

Quantitative in-vivo monitoring of bone formation in multiple myeloma patients following treatment with bortezomib: a pilot study

Induction of TAp73 expression by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia

Synergistic Action of the Human Inhibitory KIR Antibody IPH2102, and the Human CD38 Antibody Daratumumab to Enhance the Lysis of Primary Multiple Myeloma (MM) Cells in the Bone Marrow Mononuclear Cells (MNCs) from Myeloma Patients

Bortezomib restores defective apoptosis by up-regulation of Noxa in Enteropathy-associated T-cell Lymphoma

Identification of miR-155 targets in Burkitt lymphoma

Acetylation of C/EBPε is functionally important during neutrophil development

Interferon-gamma Impairs The Self-Renewal Of Hematopoietic Stem Cells

The E3 ubiquitin ligase Triad1 prevents chromosomal missegregation by regulating the checkpoint kinase Bub1

CITED2 Modulates Differentiation and Proliferation of Normal and Leukemic Hematopoietic Stem and Progenitor Cells Downstream of PU.1

Occurence of T cells specific for the proteins Crf1 and Catalase1 in SCT patients recovering from invasive aspergillosis

The chemokine receptor CXCR3 is required for the efficient recruitment of bone marrow-resident memory T cells to inflamed tissues

Multipotent Vδ2-negative γδT-cells after CMVreactivation in allogeneic stem cell transplantation

Decreased levels of circulating CCR6CD161CD8 T cells harboring cyclosporine resistance are associated with the development of graft-versus-host disease

Keynote: Antigen presentation Understanding and manipulating antigen presentation by MHC class II molecules

Molecular dissection of signals provided by activated T cells to CLL cells indicates major role for IL-21 and CD40 in controlling proliferation and chemoresistance

A High-Risk Survival Signature for Multiple Myeloma

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

Multiple HLA class I and II associations in classic Hodgkin lymphoma and EBV status defined subgroups

Towards Personalized Medicine Using a Novel Preclinical Model: Identifying Daratumumab as Effective Treatment for Multiple Myeloma

APRIL is present in the microenvionment of CLL, and affects disease progression in the TCL-1 transgenic mouse model

Improving human monocyte-derived dendritic cell vaccines by lipid nanoparticle-mediated delivery of PD-L1 and PD-L2 siRNA

Collateral Damage of Non-hematopoietic Tissue by Hematopoiesis-specific T Cells Results in GvHD During an Ongoing Profound GvL Reaction

Apoptotic blebs from leukemic cells as a source of tumor associated antigen for monocyte-derived dendritic cell loading

B and T lymphocyte attenuator mediates inhibition of MiHA-specific CD8 T cells in allogeneic stem cell transplantation patients

Rapid identification and expression analysis of minor histocompatibility antigens by whole genome association scanning and microarray gene expression analysis

Identification of New Hematopoietic Minor Histocompatibility Antigen UTA2-1; Applicable in Antitumor Immunotherapy

Constitutional t(16;21)(p13;q22) as a novel pathogenomic mechanism in a series of three new mutated FPD/AML pedigrees: implications for diagnostics

Combination of CD34/CD38 Immunophenotypes and Side Population (SP) reveals the Putative Leukemia Stem Cell/Leukemia Initiating Cell in Acute Myeloid Leukemia

High miR-212 expression predicts for better survival in cytogenetically and molecularly heterogeneous AML

Prognostic pre-transplant factors in myelodysplastic syndromes primarily treated by allogeneic HSCT: an EBMT study

High GATA-2 expression is a poor prognostic marker in pediatric Acute Myeloid Leukemia

New multiparameter approach for the identification of leukemic stem cells in acute myeloid leukemia patients

Expression of c-Met in tumor cells correlates with favorable outcome in classical Hodgkin lymphoma

Identification of a Novel B-CLL Subset Expressing Mutated Stereotypic B-Cell Receptors with Specificity for Yeast Mannan

Microenvironment Shields Myeloma from Adoptive Immunotherapy by Cell Adhesion Mediated Immune Resistance (CAM-IR)

hsTRAIL/Apo2L-Induced Apoptosis in Enteropathy-Associated T-Cell Lymphoma

Is there a germinal centre-like and activated B-cell like diffuse large B-cell lymphoma miRNA profile?

The molecular targets of Dasatinib involved in conferring CD40-mediated drug resistance in chronic lymphocytic leukemia

Deep-sequencing investigation into and KRAS mutations in myeloid malignancies

Preliminary Results from a Phase III Trial of Imatinib Versus Imatinib in Combination with Cytarabine in Patients with First Chronic Phase Myeloid Leukemia

Treatment with Lenalidomide in myelodysplastic syndromes with 5q deletion: results from the Dutch named patient program (NPP)

High Dose (HD-AraC) vs Standard Dose Cytosine Arabinoside (SD-AraC) during Induction and IL-2 vs Observation after Consolidation/Autologous stem cell transplantation in patients with Acute Myelogenous Leukemia (AML): Final report of the AML-12 randomized phase III trial of EORTC and GIMEMA Leukemia Groups on the value of High Dose AraC

The Impact of Prophylactic Fresh Frozen Plasma On Venous Thromboembolism in Adults Treated for Acute Lymphoblastic Leukemia

The direct treatment costs for patients with acute myeloid leukemia

Erythropoiesis and globin switching in compound mutant mice

Regulation of erythrocyte shape through LYN-induced tyrosine phosphorylation and downstream events

Identification of novel cytokines and chemokines that induce HSC expansion

The transcription factor MEIS1 regulates early erythroid and megakaryocytic cell fate

Central memory CD8 T cells regulate hematopoietic stem cell function

Mouse versus human extrinsic cues dictate transformation potential in BCR-ABL/BMI1-induced leukemia in human xenograft models

CEBPα Is a Transcriptional Repressor of T-Cell Related Genes Explaining the Myeloid/T-Lymphoid Features of CEBPα-Silenced AML

GFI1 is a direct target of the oncofusion protein AML1-ETO in acute myeloid leukemia

Polycomb Group Complex 1 Composition determines Hematopoietic Stem Cell fate

Mutations in TET2 and IDH in patients with acute myeloid leukemia perturb a common epigenetic pathway resulting in decreased 5-hydroxymethylcytosine levels

Genetic defects in PRC2 components other than are not common in myeloid malignancies

PRC1 complex composition dictates locus-specific polycomb-mediated repression in human stem/progenitor cells

Flow cytometry in myelodysplastic syndromes. Definitions, Clinical and Diagnostic Applications

Rol van multiparameter flowcytometrie bij multipel myeloom

Trombo-elastografie en massaal bloedverlies

Double hit lymfoom

Multiple Myeloma Recent developments and controversies

Maligne lymfoom, nieuwe ontwikkelingen op gebied van imaging

The extracellular matrix protein Slit3 promotes erythropoiesis

Matrix protein βig-h3 function in hematopoietic and stromal cells

Plasma Membrane proteomics on human HSCs/MPPs/LSCs

The role of the class III PI3K Vps34 in regulation of normal and malignant hematopoiesis

In vivo T-cell depletion using rabbit derived ATG leads to an increased EBV-PTLD risk due to an induced imbalance between B and T-cell recovery which is not seen after horse derived ATG or alemtuzumab

Promising efficacy of combined inolimomab and etanercept in severe steroid-refractory acute graft-versus-host disease (aGVHD)

Treatment of steroid resistant grade II to IV acute GVHD by infusion of mesenchymal stroma cells expanded with human plasma and platelet lysate - a phase I/II study

Improved outcome following Intensive Care Unit support within 100 days after allogeneic Haematopoietic Stem Cell Transplant

R-DHAP Immuno-Chemotherapy Is An Effective Remission-Induction Treatment for Fludarabine Refractory CLL Patients: Interim Analysis of the Dutch-Belgian Prospective Multicenter HOVON88 Trial

Diminished Asparaginase Turnover Due to a Germline Mutation in Cathepsin B

Alemtuzumab treatment can affect CD52 positive as well as CD52 negative GPI-deficient Sizary cells allowing long-term disease control

Are we on the right track? Incidence, survival and mortality from plasma cell malignancies in the Netherlands in the last two decades: results from a population based study

Gene expression profiling, high-density genome-wide genotyping and copy number analyses of adult acute lymphoblastic leukemia

High class II-associated invariant chain peptide (CLIP) expression on residual leukemic cells is associated with increased relapse risk in acute myeloid leukemia

MicroRNA Expression Profiling of Hematopoietic and Leukemic Stem Cells in Acute Myeloid Leukemia

Exome Sequencing of Late Recurrence T-Cell ALL in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes

Targeting of Acute Myeloid Leukemia (stem) cells by anti-CLEC12A Antibody-Drug-Conjugates and Bispecific CLL-1xCD3 BiTE Antibody

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

How I treat: kleine klonen, grote gevolgen

How I treat “schimmel”

“How I treat”: Trombotische trombocytopenische purpura

Uniparental isodisomy and progressive clonal selection: a common mechanism causing late onset beta-thalassemia Major?

Increasing the dose of rabbit-ATG does not lead to a higher response rate in the first line treatment of severe aplastic anemia

Arterial thrombosis in Von Willebrand Disease

Response to desmopressin in hemophilia A patients with low FVIII levels

Hemarthrosis results in an increase in Articular Fibrinolytic activity in Hemophilic Mice

Voriconazole concentrations are significantly influenced by inflammatory reactions

Past, present, and future of Myelodysplastic syndromes

Weibel-Palade bodies en hun rol bij de ziekte van Von Willebrand

Trombose profylaxe bij zwangeren

Nieuwe antithrombotica: wanneer, welke en hoe veilig zijn ze?

Acute myeloïde leukemie en de rol van autologe stamceltransplantatie

Allogeneic stem cell transplantation for patients with AML in remission: an integrated risk adapted approach

Het Hodgkin lymfoom: PET en nieuwe middelen