Abstractbooks

Increased incidence of T-cell malignancies in patients with chronic lymphocytic leukaemia

Goda Choi, Esther C. van den Broek, Olga C.G. Stam, Carel J.M. van Noesel, Sanne H. Tonino, Arnon P. Kater

Outcome and minimal residual disease monitoring in adult acute lymphoblastic leukemia patients treated with pre-induction therapy (Groningen regimen)

B. Klein Schaarsberg, M. Bellido, R. Bekkema, A.B. Mulder, E. van den Berg, J.C. Kluin-Nelemans, S. Daenen

Improving hospital care for patients with non-Hodgkin’s lymphomas: preliminary results of a clustered randomized controlled trial

Jozette J.C. Stienen, Petronella B. Ottevanger, Johan H.J.M. van Krieken, Nicole M.A. Blijlevens, Rosella P.M.G. Hermens

Bone-marrow niche derived R-spondins facilitate Wnt/β-catenin signalling in multiple myeloma via aberrantly expressed LGR4

Harmen van Andel, Iris Koopmans, Wim de Lau, Alex de Bruin, Sander P. Joosten, Marie-José Kersten, Marcel Spaargaren, Steven T. Pals

Understanding the role of B-cell receptor signaling in development of chronic lymphocytic leukemia using novel mouse cell lines

Saravanan Yuvaraj Pillai, Simar Pal Singh, Marjolein J.W. de Bruijn, Alice F. Muggen, Anton W. Langerak, Rudi W. Hendriks

Long noncoding RNAs, a novel component of the Myc transcriptional network

Melanie Winkle, Anke van den Berg, Masoumeh Tayari, Jantine Sietzema, Martijn Terpstra, Gertrud Kortman, Debora de Jong, Lydia Visser, Arjan Diepstra, Klaas Kok, Joost Kluiver

NF-kB signaling prevents DNA damage in pre-B cells by suppressing RAG1/2 expression and activity

Mahnoush Bahjat, Katarina Ochodnicka-Mackovicova, Chiel Maas, Alexander de Bruin, Richard Bende, Carel van Noesel, Jeroen Guikema

Oncogenic miRNAs in Hodgkin lymphoma cell lines

Ye Yuan, Jasper Koerts, Bea Rutgers, Lydia Visser, Joost Kluiver, Anke van den Berg

Prevalence of hematological abnormalities in potential stem cell donors

Juultje Martens, Mirjam Fechter, Anneke Brand, Jaap Jan Zwaginga, Tanja Netelenbos

The comparative value of hematopoietic stem cell transplantation and chemotherapy in cytogenetically normal AML subclassified by NPM1 mutation status and FLT3-ITD allelic ratio

Jurjen Versluis, Raynier Devillier, Florentien in 't Hout, Wim van Putten, Markus Manz, Marie-Christiane Vekemans, Ron Schaafsma, Jakob Passweg, Johan Maertens, Jurgen Kuball, Leo Verdonck, Bart Biemond, Peter Valk, Marie-Joelle Mozziconacci, Norbert Vey, Harry Schouten, Edo Vellenga, Thomas Pabst, Bob Lowenberg, Gert Ossenkoppele, Didier Blaise, Gerwin Huls, Jan Cornelissen

Post-remission treatment with allogeneic stem cell transplantation improves outcome in patients aged 60 years and older with acute myeloid leukemia in first remission

Jurjen Versluis, Carin Hazenberg, Wim van Putten, Jakob Passweg, Johan Maertens, Bart Biemond, Harry Schouten, Thomas Pabst, Bob Löwenberg, Gert Ossenkoppele, Edo Vellenga, Jan Cornelissen

A rationale for reduced-frequency dosing of anidulafungin for antifungal prophylaxis in immunocompromised patients

Bruggemann, Walter van der Velden, Catherijne Knibbe, Angela Colbers, Stephan Hol, David Burger, Peter Donnelly, Nicole Blijlevens

Superiority of (in vitro) 3D niche-mimicking system applied in MSC and HSC co-culturing and its impact on hematopoietic support

Maja Maria Paciejewska-Exalto, Carlijn Kuijk, Carlijn Voermans

The humanized scaffold model 2.0: Implementation of human blood vessels in human bone-marrow-like scaffold model

Willy A Noort, Regina de Jong-Korlaar, Linda Lubbers-Aalders, Patricia van Hamersveld, Kevin van Dal, Joost D de Bruijn, Huipin Yuan, Anton CM Martens, Richard WJ Groen

Establishing human niche xenograft models for myeloid and lymphoid leukemia driven by MLL-AF9

Marco Carretta, Jenny Jaques, Bauke De Boer, Anton C. Martens, Edo Vellenga, Richard W.J. Groen, Jan Jacob Schuringa

CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa

Erik Slinger, Eric Eldering, Arnon Kater

Age dependent HLA associations in classical Hodgkin lymphoma

Kushi Kushekhar, Ilja Nolte, Bouke Hepkema, Henrik Hjalgrim, Karin E Smedby, Ruth Jarrett, Rianne Veenstra, Klaus Rostaard, Lydia Visser, Arjan Diepstra, Anke van den Berg

Screening for affinity divergent CD38 antibodies and their translation into CD38 Chimeric antigen receptors

Esther Drent, J. Lammerts van Bueren, R. Rademaker, T. Riedl, D. Verzijl, P. Parren, N. van de Donk, H. Lokhorst, T. Mutis

Determining and manipulating MCL-1 expression in primary B cell malignancies

Victor Peperzak, Ingela Vikstrom, Erik Slinger, Harmen van Andel, Ingrid Derks, Marie Jose Kersten, Marcel Spaargaren, Arnon Kater, Eric Eldering

Integrated V617F, exon 12, and mutational screening in myeloproliferative neoplasms by next generation sequencing

Aniek O. de Graaf, Marion Massop, Bert A. van der Reijden, Joop H. Jansen

Erythroid analysis by flow cytometry strongly adds to MDS diagnosis: A report on behalf of the HOVON89 Study Group

Eline MP Cremers, Theresia M Westers, Canan Alhan, Claudia Cali, Heleen A Visser-Wisselaar, Dana A Chitu, Marian JPL Stevens-Kroef, Pedro Silva Coelho, Edo Vellenga, Saskia K. Klein, Pierre W. Wijermans, Georgina E. de Greef, Marie-Cecile Legdeur, Petra Muus, Gert J Ossenkoppele, Joop H Jansen, Arjan A van de Loosdrecht

Identification of chromosomal abnormalities by microarray-based genomic profiling as compared to karyotyping in patients with low and intermediate-1 risk myelodysplastic syndromes within a prospective clinical trial: a study on behalf of the HOVON89 Study Group

Marian Stevens-Kroef, Daniel Olde Weghuis, Najat ElIdrissi-Zaynoun, Bert van der Reijden, Eline Cremers, C. Alhan, T.M. Westers, Heleen Visser-Wisselaar, D.A. Chitu, Edo Vellenga, S.K. KLein, P.W. Wijermans, G.E. de Greef, Ron Schaafsma, M van Marwijk-Kooy, Petra Muus, G.J. Ossenkoppele, Arjan van de Loosdrecht, Joop Jansen

Towards a further refinement of current risk classification in acute myeloid leukemia

Wendelien Zeijlemaker, Angele Kelder, Yvonne JM Oussoren- Brockhoff, Willemijn J Scholten, Alexander N Snel, Dennis Veldhuizen, Jacqueline Cloos, Gert J Ossenkoppele, Gerrit J Schuurhuis

Extensive Molecular Analysis Strongly Improves the Distinction Between AML and ALL in Adult acute leukemias of ambiguous lineage

Anikó Szabó, Mathijs A. Sanders, Carla Exalto, Jasper E. Koenders, Patricia G. Hoogeveen, Anita M. Schelen, Willemijn van den Ancker, Arjan A. van de Loosdrecht, Bob Löwenberg, Vincent H.J. van der Velden, Jan J. Cornelissen, Peter Valk, Anita W. Rijneveld

Trends in incidence, primary treatment and survival of chronic myelomonocytic leukemia: a nationwide population-based study among 1,359 patients diagnosed in the Netherlands from 1989 to 2012

Avinash G Dinmohamed, Mirian Brink, Otto Visser, Pieter Sonneveld, Arjan A van de Loosdrecht, Mojca Jongen-Lavrencic, Georgine E de Greef

Streptamer isolated multi-antigen specific T cells contain tumor associated antigen reactive donor T cells as elementary component

M.C.J. Roex, E. van Liempt, L. Hageman, L. Germeroth, C.J.M Halkes, J.H.F Falkenburg, I. Jedema

The aryl hydrocarbon receptor antagonist stemregenin 1 stimulates expression of NK cell related transcription factors, thereby it facilitates generation of highly functional NK cells in vitro

Mieke W.H. Roeven, Soley Thordardottir, Arwa Kohela, Frans Maas, Joop Janssen, Nicole M. Blijlevens, Jeanette Cany, Nicolaas Schaap, Harry Dolstra

The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing

Fazlyn Reeny Abdul Razak, Yuxuan Liu, Martijn Terpstra, Fong Chun Chan, Ali Saber, Marcel Nijland, Gustaaf van Imhoff, Lydia Visser, Randy Gascoyne, Christian Steidl, Joost Kluiver, Arjan Diepstra, Klaas Kok, Anke van den Berg

TCRgd+ T-LGL cells are effector TCRgd+ T cells with disturbed proliferation and apoptosis

Martine Kallemeijn, Yorick Sandberg, Joyce Schilperoord-Vermeulen, Dick de Ridder, Jacques van Dongen, Ton Langerak

Co-operative role of colony stimulating factor 3 receptor and runt-related transcription factor 1 mutations in leukemic progression from severe congenital neutropenia

Julia C. Obenauer, Paulina M.H. van Strien, Gang Huang, Marry M. van den Heuvel-Eibrink, Ivo P. Touw

Mutations in ELANE and HAX1 lead to elevated ROS levels and diminished hematopoietic differentiation potential in an human induced pluripotent stem cell model of severe congenital neutropenia

P.A. Olofsen, P. Maczuga, P.M.H. van Strien, I.P. Touw

Selective mRNA translation controls erythropoiesis: regulation and function of the RNA-binding protein Csde1

Kat Moore, Rastislav Horos, Carmen van der Zwaan, Sander Meijer, Peter-Bram 't Hoen, Marieke von Lindern

Increased formation and increased degradation of fibrin clots in solvent-detergent plasma: a 72 hour observation study between Omniplasma and Quarantine plasma

Joyce J.B.C. van Beers, Lieve T. van Egmond, Rick J.H. Wetzels, Erik A. M. Beckers, René van Oerle, Ron J.M.H.E. Straat, Yvonne M.C. Henskens

Influence of INR level on the agreement between capillary and venous INR results

Joseph S. Biedermann, Frank W.G. Leebeek, Peter N. Buhre, Sacha de Lathouder, Jan P.F. Barends, Moniek P.M. de Maat, Felix J.M. van der Meer, Marieke J.H.A. Kruip

Population pharmacokinetics in Hemophilia A: Towards individualization of perioperative replacement therapy

H.C.A.M. Hazendonk, J. Lock, K. Fijnvandraat, F.J.M. van der Meer, K. Meijer, B.A.P. Laros-van Gorkom, M. Driessens, F.W.G. Leebeek, R.A.A. Mathôt, M.H. Cnossen

Overdosing of replacement therapy in perioperative von Willebrand patients: a need for patient-tailored therapy

H.C. Veerman, H.C.A.M. Hazendonk, Y.V. Sanders, F.W.G. Leebeek, M.H. Cnossen

Combining lenalidomide and cyclophosphamide is synergistic and has clear immune-modulating effects in lenalidomide refractory patients

L. E. Franssen, Inger S. Nijhof, S. Zweegman, Mark-David Levin, Harry R. Koene, A. Beeker, A. C. Bloem, G. M.J. Bos, L. M. Faber, S. K. Klein, E. J.F.M. de Kruijf, E. van der Spek, S. Wittebol, J. van Velzen, B. van Kessel, T. Mutis, P. Sonneveld, H. M. Lokhorst, Niels W.C.J. van de Donk

Modulation of CD38 expression levels on multiple myeloma cells by all-trans retinoic acid improves the efficacy of the anti-CD38 monoclonal antibody daratumumab

Inger S. Nijhof, Henk M. Lokhorst, Berris van Kessel, Richard W.J. Groen, Anton C. Martens, Willy A. Noort, Regina de Jong-Korlaar, Parul Doshi, Saskia K. Klein, Tuna Mutis, Kate Sasser, Niels W.C.J. van de Donk

Anaemia in general practice: causes and survival

Karlijn Stouten, Jurgen A. Riedl, Pieter Sonneveld, Mark David Levin

Characterisation of reticulocyte differentiation: from in vivo to in vitro

Elina Ovchynnikova, Marea van der Rijst, Emile van den Akker, Marieke von Lindern

Complement activation in AIHA as footprint for difficult-to-detect IgM-autoantibodies

Elisabeth Meulenbroek, Conny Brouwer, Claudia Folman, Masja de Haas, Rien van Oers, Sacha Zeerleder, Diana Wouters

Increased risk of development of malignancies in adult patients treated with antithymocyte globulin as first line treatment for acquired aplastic anaemia

Joost GK van der Hem, Liesbeth C de Wreede, Anneke Brand, Hendrik Veelken, Fred Falkenburg, Constantijn JM Halkes

An alternative ITGB2 splice variant encodes a novel hematopoietic restricted minor histocompatibility antigen with therapeutic relevance

Margot J. Pont, Dyantha I. van der Lee, Edith D. van der Meijden, Cornelis A.M. van Bergen, M. Willy Honders, Matthias Eefting, Peter-Bram A. 't Hoen, J.H. Frederik Falkenburg, Marieke Griffioen

Inhibition of Akt-signalling promotes the generation of superior tumour-reactive T cells for adoptive immunotherapy

Anniek B van der Waart, Noortje MP van de Weem, Frans Maas, Cynthia SM Kramer, Michel GD Kester, JH Frederik Falkenburg, Nicolaas Schaap, Joop H Jansen, Robbert van der Voort, Luca Gattinoni, Willemijn Hobo, Harry Dolstra

In vitro generation of HLA-DP-restricted donor T cells with hematopoiesis specificity

Aicha Laghmouchi, Conny Hoogstraten, J.H. Frederik Falkenburg, Inge Jedema

T-cell receptors (TCRs) specific for the intracellular transcription factor Bob1 allow efficient targeting of human B-cell leukemia and multiple myeloma

Lorenz Jahn, Pleun Hombrink, Renate S. Hagedoorn, Dirk M. van der Steen, Michel G.D. Kester, Chopie Hassan, Marjolein P. Schoonakker, Erwin P. van der Pijl, Peter A. van Veelen, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk

Abstracts van het 9e Dutch Hematology congress 2015

Ex vivo generation of human plasmacytoid and myeloid dendritic cell-based vaccines from CD34+ hematopoietic progenitor cells

Soley Thordardottir, Basav N. Hangalapura, Tim Hutten, Marta Cossu, Jan Spanholtz, Nicolaas Schaap, Timothy Radstake, Robbert van der Voort, Willemijn Hobo, Harry Dolstra

Vitiligo after allogeneic stem cell transplantation associated with the presence of donor CD4 T-cells recognizing a melanocyte specific MiHA

P. van Balen, E.G.A. Lurvink, M. van de Meent, M.W. Honders, J.J. Out-Luiting, N.A. Gruis, J.H.F. Falkenburg, M. Griffioen

High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations

Davide Monteferrario, Sylvie M Noordermeer, Saskia Bergevoet, Gerwin Huls, Joop H Jansen, Bert A van der Reijden

Phosphoproteomics of a panel of AML cell lines reveals oncogenic signaling and candidate drivers

Carolien van Alphen, Jacqueline Cloos, Sander R. Piersma, Jaco C. Knol, Thang V. Pham, Gert J. Ossenkoppele, Henk Verheul, Connie R. Jimenez, Jeroen J.W.M. Janssen

Clonal analysis of human hematopoiesis by cellular barcoding

Mirjam Belderbos, Gerald de Haan, Taco Koster, Leonid Bystrykh

Potent human graft versus acute leukemia responses are mediated by cytotoxic antibodies

Marijn Gillissen, Etsuko Yasuda, Sophie Levie, Arjen Bakker, Martijn Kedde, Yvonne Claassen, Cynthia Huisman, Tim Beaumont, Pauline van Helden, Hergen Spits, Mette Hazenberg

Massive parallel sequencing of full-length B-cell receptor sequences reveals HLA-dependent shaping of the B-cell immune repertoire

Marvyn T. Koning, Sander A.J. van der Zeeuw, Marcelo Navarrete, Cornelis A.M. van Bergen, Valeri Nteleah, Marieke Griffioen, Szymon M. Kielbasa, Hendrik Veelken

Dendritic cell subsets in myelodysplastic syndromes

N Kerkhoff, T.M. Westers, H.J. Bontkes, R. Mebius, S. Kordasti, G.J. Mufti, T.D. de Gruijl, A.A. van de Loosdrecht

Essential role for non-canonical PRC1.1 in leukemia independent of the canonical PRC2/PRC1 axis

Henny Maat, Vincent van den Boom, Marjan Geugien, Ana Sotoca, Jenny Jaques, Annet Brouwers-Vos, Fabrizia Fusetti, Henk Stunnenberg, Edo Vellenga, Joost Martens, Jan Jacob Schuringa

Loss of ASXL1 triggers an apoptotic response in human hematopoietic stem and progenitor cells

Susan Hilgendorf, Hendrik Folkerts, Jan-Jacob Schuringa, Edo Vellenga

Tumor suppressor genes and cooperate in leukemia development and glucocorticoid therapy resistance

Esther Tijchon, Rene Marke, Dorette van Ingen Schenau, Judith M Boer, Marc Demkes, Liesbeth van Emst, Laurens T van der Meer, Roland P Kuiper, Peter M Hoogerbrugge, Monique L den Boer, Frank N van Leeuwen, Blanca Scheijen

miRNA-125a expands multilineage long-term repopulating activity to hematopoietic stem cells and multipotent progenitors

Edyta E Wojtowicz, Peter van Veelen, Mathilde JC Broekhuis, Hans WJ de Looper, Ellen Weersing, Martha Ritsema, Farshid M Alemdehy, Stefan J Erkeland, Leonid V Bystrykh, Gerald de Haan

Huidig nummer

Jaargang 12, Abstractboek, Februari 2015

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Inhoudsopgave Jaargang 12, Abstractboek, Februari 2015

Abstractbooks

Abstracts van het 9e Dutch Hematology congress 2015

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