Jaargang 12, Abstractboek DHC, Februari 2015



Streptamer isolated multi-antigen specific T cells contain tumor associated antigen reactive donor T cells as elementary component

A rationale for reduced-frequency dosing of anidulafungin for antifungal prophylaxis in immunocompromised patients

Superiority of (in vitro) 3D niche-mimicking system applied in MSC and HSC co-culturing and its impact on hematopoietic support

The humanized scaffold model 2.0: Implementation of human blood vessels in human bone-marrow-like scaffold model

Establishing human niche xenograft models for myeloid and lymphoid leukemia driven by MLL-AF9

CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa

Age dependent HLA associations in classical Hodgkin lymphoma

Screening for affinity divergent CD38 antibodies and their translation into CD38 Chimeric antigen receptors

Determining and manipulating MCL-1 expression in primary B cell malignancies

Integrated V617F, exon 12, and mutational screening in myeloproliferative neoplasms by next generation sequencing

Erythroid analysis by flow cytometry strongly adds to MDS diagnosis: A report on behalf of the HOVON89 Study Group

Identification of chromosomal abnormalities by microarray-based genomic profiling as compared to karyotyping in patients with low and intermediate-1 risk myelodysplastic syndromes within a prospective clinical trial: a study on behalf of the HOVON89 Study Group

Towards a further refinement of current risk classification in acute myeloid leukemia

Extensive Molecular Analysis Strongly Improves the Distinction Between AML and ALL in Adult acute leukemias of ambiguous lineage

Trends in incidence, primary treatment and survival of chronic myelomonocytic leukemia: a nationwide population-based study among 1,359 patients diagnosed in the Netherlands from 1989 to 2012

Post-remission treatment with allogeneic stem cell transplantation improves outcome in patients aged 60 years and older with acute myeloid leukemia in first remission

The aryl hydrocarbon receptor antagonist stemregenin 1 stimulates expression of NK cell related transcription factors, thereby it facilitates generation of highly functional NK cells in vitro

Ex vivo generation of human plasmacytoid and myeloid dendritic cell-based vaccines from CD34+ hematopoietic progenitor cells

Vitiligo after allogeneic stem cell transplantation associated with the presence of donor CD4 T-cells recognizing a melanocyte specific MiHA

High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations

Phosphoproteomics of a panel of AML cell lines reveals oncogenic signaling and candidate drivers

Clonal analysis of human hematopoiesis by cellular barcoding

Potent human graft versus acute leukemia responses are mediated by cytotoxic antibodies

Massive parallel sequencing of full-length B-cell receptor sequences reveals HLA-dependent shaping of the B-cell immune repertoire

Dendritic cell subsets in myelodysplastic syndromes

Essential role for non-canonical PRC1.1 in leukemia independent of the canonical PRC2/PRC1 axis

Loss of ASXL1 triggers an apoptotic response in human hematopoietic stem and progenitor cells

Tumor suppressor genes and cooperate in leukemia development and glucocorticoid therapy resistance

miRNA-125a expands multilineage long-term repopulating activity to hematopoietic stem cells and multipotent progenitors


An alternative ITGB2 splice variant encodes a novel hematopoietic restricted minor histocompatibility antigen with therapeutic relevance

TCRgd+ T-LGL cells are effector TCRgd+ T cells with disturbed proliferation and apoptosis

Co-operative role of colony stimulating factor 3 receptor and runt-related transcription factor 1 mutations in leukemic progression from severe congenital neutropenia

Mutations in ELANE and HAX1 lead to elevated ROS levels and diminished hematopoietic differentiation potential in an human induced pluripotent stem cell model of severe congenital neutropenia

Selective mRNA translation controls erythropoiesis: regulation and function of the RNA-binding protein Csde1

Increased formation and increased degradation of fibrin clots in solvent-detergent plasma: a 72 hour observation study between Omniplasma and Quarantine plasma

Influence of INR level on the agreement between capillary and venous INR results

Population pharmacokinetics in Hemophilia A: Towards individualization of perioperative replacement therapy

Overdosing of replacement therapy in perioperative von Willebrand patients: a need for patient-tailored therapy

Combining lenalidomide and cyclophosphamide is synergistic and has clear immune-modulating effects in lenalidomide refractory patients

Modulation of CD38 expression levels on multiple myeloma cells by all-trans retinoic acid improves the efficacy of the anti-CD38 monoclonal antibody daratumumab

Anaemia in general practice: causes and survival

Characterisation of reticulocyte differentiation: from in vivo to in vitro

Complement activation in AIHA as footprint for difficult-to-detect IgM-autoantibodies

Increased risk of development of malignancies in adult patients treated with antithymocyte globulin as first line treatment for acquired aplastic anaemia

The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing

Inhibition of Akt-signalling promotes the generation of superior tumour-reactive T cells for adoptive immunotherapy

In vitro generation of HLA-DP-restricted donor T cells with hematopoiesis specificity

T-cell receptors (TCRs) specific for the intracellular transcription factor Bob1 allow efficient targeting of human B-cell leukemia and multiple myeloma

Increased incidence of T-cell malignancies in patients with chronic lymphocytic leukaemia

Outcome and minimal residual disease monitoring in adult acute lymphoblastic leukemia patients treated with pre-induction therapy (Groningen regimen)

Improving hospital care for patients with non-Hodgkin's lymphomas: preliminary results of a clustered randomized controlled trial

Bone-marrow niche derived R-spondins facilitate Wnt/β-catenin signalling in multiple myeloma via aberrantly expressed LGR4

Understanding the role of B-cell receptor signaling in development of chronic lymphocytic leukemia using novel mouse cell lines

Long noncoding RNAs, a novel component of the Myc transcriptional network

NF-kB signaling prevents DNA damage in pre-B cells by suppressing RAG1/2 expression and activity

Oncogenic miRNAs in Hodgkin lymphoma cell lines

Prevalence of hematological abnormalities in potential stem cell donors

The comparative value of hematopoietic stem cell transplantation and chemotherapy in cytogenetically normal AML subclassified by NPM1 mutation status and FLT3-ITD allelic ratio