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Jaargang 12, Abstractboek, Februari 2015

Inhoudsopgave Jaargang 12, Abstractboek, Februari 2015

Abstractbooks

Increased incidence of T-cell malignancies in patients with chronic lymphocytic leukaemia
Goda Choi, Esther C. van den Broek, Olga C.G. Stam, Carel J.M. van Noesel, Sanne H. Tonino, Arnon P. Kater
Outcome and minimal residual disease monitoring in adult acute lymphoblastic leukemia patients treated with pre-induction therapy (Groningen regimen)
B. Klein Schaarsberg, M. Bellido, R. Bekkema, A.B. Mulder, E. van den Berg, J.C. Kluin-Nelemans, S. Daenen
Improving hospital care for patients with non-Hodgkin’s lymphomas: preliminary results of a clustered randomized controlled trial
Jozette J.C. Stienen, Petronella B. Ottevanger, Johan H.J.M. van Krieken, Nicole M.A. Blijlevens, Rosella P.M.G. Hermens
Bone-marrow niche derived R-spondins facilitate Wnt/β-catenin signalling in multiple myeloma via aberrantly expressed LGR4
Harmen van Andel, Iris Koopmans, Wim de Lau, Alex de Bruin, Sander P. Joosten, Marie-José Kersten, Marcel Spaargaren, Steven T. Pals
Understanding the role of B-cell receptor signaling in development of chronic lymphocytic leukemia using novel mouse cell lines
Saravanan Yuvaraj Pillai, Simar Pal Singh, Marjolein J.W. de Bruijn, Alice F. Muggen, Anton W. Langerak, Rudi W. Hendriks
Long noncoding RNAs, a novel component of the Myc transcriptional network
Melanie Winkle, Anke van den Berg, Masoumeh Tayari, Jantine Sietzema, Martijn Terpstra, Gertrud Kortman, Debora de Jong, Lydia Visser, Arjan Diepstra, Klaas Kok, Joost Kluiver
NF-kB signaling prevents DNA damage in pre-B cells by suppressing RAG1/2 expression and activity
Mahnoush Bahjat, Katarina Ochodnicka-Mackovicova, Chiel Maas, Alexander de Bruin, Richard Bende, Carel van Noesel, Jeroen Guikema
Oncogenic miRNAs in Hodgkin lymphoma cell lines
Ye Yuan, Jasper Koerts, Bea Rutgers, Lydia Visser, Joost Kluiver, Anke van den Berg
Prevalence of hematological abnormalities in potential stem cell donors
Juultje Martens, Mirjam Fechter, Anneke Brand, Jaap Jan Zwaginga, Tanja Netelenbos
The comparative value of hematopoietic stem cell transplantation and chemotherapy in cytogenetically normal AML subclassified by NPM1 mutation status and FLT3-ITD allelic ratio
Jurjen Versluis, Raynier Devillier, Florentien in 't Hout, Wim van Putten, Markus Manz, Marie-Christiane Vekemans, Ron Schaafsma, Jakob Passweg, Johan Maertens, Jurgen Kuball, Leo Verdonck, Bart Biemond, Peter Valk, Marie-Joelle Mozziconacci, Norbert Vey, Harry Schouten, Edo Vellenga, Thomas Pabst, Bob Lowenberg, Gert Ossenkoppele, Didier Blaise, Gerwin Huls, Jan Cornelissen
Post-remission treatment with allogeneic stem cell transplantation improves outcome in patients aged 60 years and older with acute myeloid leukemia in first remission
Jurjen Versluis, Carin Hazenberg, Wim van Putten, Jakob Passweg, Johan Maertens, Bart Biemond, Harry Schouten, Thomas Pabst, Bob Löwenberg, Gert Ossenkoppele, Edo Vellenga, Jan Cornelissen
A rationale for reduced-frequency dosing of anidulafungin for antifungal prophylaxis in immunocompromised patients
Bruggemann, Walter van der Velden, Catherijne Knibbe, Angela Colbers, Stephan Hol, David Burger, Peter Donnelly, Nicole Blijlevens
Superiority of (in vitro) 3D niche-mimicking system applied in MSC and HSC co-culturing and its impact on hematopoietic support
Maja Maria Paciejewska-Exalto, Carlijn Kuijk, Carlijn Voermans
The humanized scaffold model 2.0: Implementation of human blood vessels in human bone-marrow-like scaffold model
Willy A Noort, Regina de Jong-Korlaar, Linda Lubbers-Aalders, Patricia van Hamersveld, Kevin van Dal, Joost D de Bruijn, Huipin Yuan, Anton CM Martens, Richard WJ Groen
Establishing human niche xenograft models for myeloid and lymphoid leukemia driven by MLL-AF9
Marco Carretta, Jenny Jaques, Bauke De Boer, Anton C. Martens, Edo Vellenga, Richard W.J. Groen, Jan Jacob Schuringa
CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa
Erik Slinger, Eric Eldering, Arnon Kater
Age dependent HLA associations in classical Hodgkin lymphoma
Kushi Kushekhar, Ilja Nolte, Bouke Hepkema, Henrik Hjalgrim, Karin E Smedby, Ruth Jarrett, Rianne Veenstra, Klaus Rostaard, Lydia Visser, Arjan Diepstra, Anke van den Berg
Screening for affinity divergent CD38 antibodies and their translation into CD38 Chimeric antigen receptors
Esther Drent, J. Lammerts van Bueren, R. Rademaker, T. Riedl, D. Verzijl, P. Parren, N. van de Donk, H. Lokhorst, T. Mutis
Determining and manipulating MCL-1 expression in primary B cell malignancies
Victor Peperzak, Ingela Vikstrom, Erik Slinger, Harmen van Andel, Ingrid Derks, Marie Jose Kersten, Marcel Spaargaren, Arnon Kater, Eric Eldering
Integrated V617F, exon 12, and mutational screening in myeloproliferative neoplasms by next generation sequencing
Aniek O. de Graaf, Marion Massop, Bert A. van der Reijden, Joop H. Jansen
Erythroid analysis by flow cytometry strongly adds to MDS diagnosis: A report on behalf of the HOVON89 Study Group
Eline MP Cremers, Theresia M Westers, Canan Alhan, Claudia Cali, Heleen A Visser-Wisselaar, Dana A Chitu, Marian JPL Stevens-Kroef, Pedro Silva Coelho, Edo Vellenga, Saskia K. Klein, Pierre W. Wijermans, Georgina E. de Greef, Marie-Cecile Legdeur, Petra Muus, Gert J Ossenkoppele, Joop H Jansen, Arjan A van de Loosdrecht
Identification of chromosomal abnormalities by microarray-based genomic profiling as compared to karyotyping in patients with low and intermediate-1 risk myelodysplastic syndromes within a prospective clinical trial: a study on behalf of the HOVON89 Study Group
Marian Stevens-Kroef, Daniel Olde Weghuis, Najat ElIdrissi-Zaynoun, Bert van der Reijden, Eline Cremers, C. Alhan, T.M. Westers, Heleen Visser-Wisselaar, D.A. Chitu, Edo Vellenga, S.K. KLein, P.W. Wijermans, G.E. de Greef, Ron Schaafsma, M van Marwijk-Kooy, Petra Muus, G.J. Ossenkoppele, Arjan van de Loosdrecht, Joop Jansen
Towards a further refinement of current risk classification in acute myeloid leukemia
Wendelien Zeijlemaker, Angele Kelder, Yvonne JM Oussoren- Brockhoff, Willemijn J Scholten, Alexander N Snel, Dennis Veldhuizen, Jacqueline Cloos, Gert J Ossenkoppele, Gerrit J Schuurhuis
Extensive Molecular Analysis Strongly Improves the Distinction Between AML and ALL in Adult acute leukemias of ambiguous lineage
Anikó Szabó, Mathijs A. Sanders, Carla Exalto, Jasper E. Koenders, Patricia G. Hoogeveen, Anita M. Schelen, Willemijn van den Ancker, Arjan A. van de Loosdrecht, Bob Löwenberg, Vincent H.J. van der Velden, Jan J. Cornelissen, Peter Valk, Anita W. Rijneveld
Trends in incidence, primary treatment and survival of chronic myelomonocytic leukemia: a nationwide population-based study among 1,359 patients diagnosed in the Netherlands from 1989 to 2012
Avinash G Dinmohamed, Mirian Brink, Otto Visser, Pieter Sonneveld, Arjan A van de Loosdrecht, Mojca Jongen-Lavrencic, Georgine E de Greef
Streptamer isolated multi-antigen specific T cells contain tumor associated antigen reactive donor T cells as elementary component
M.C.J. Roex, E. van Liempt, L. Hageman, L. Germeroth, C.J.M Halkes, J.H.F Falkenburg, I. Jedema
The aryl hydrocarbon receptor antagonist stemregenin 1 stimulates expression of NK cell related transcription factors, thereby it facilitates generation of highly functional NK cells in vitro
Mieke W.H. Roeven, Soley Thordardottir, Arwa Kohela, Frans Maas, Joop Janssen, Nicole M. Blijlevens, Jeanette Cany, Nicolaas Schaap, Harry Dolstra
The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing
Fazlyn Reeny Abdul Razak, Yuxuan Liu, Martijn Terpstra, Fong Chun Chan, Ali Saber, Marcel Nijland, Gustaaf van Imhoff, Lydia Visser, Randy Gascoyne, Christian Steidl, Joost Kluiver, Arjan Diepstra, Klaas Kok, Anke van den Berg
TCRgd+ T-LGL cells are effector TCRgd+ T cells with disturbed proliferation and apoptosis
Martine Kallemeijn, Yorick Sandberg, Joyce Schilperoord-Vermeulen, Dick de Ridder, Jacques van Dongen, Ton Langerak
Co-operative role of colony stimulating factor 3 receptor and runt-related transcription factor 1 mutations in leukemic progression from severe congenital neutropenia
Julia C. Obenauer, Paulina M.H. van Strien, Gang Huang, Marry M. van den Heuvel-Eibrink, Ivo P. Touw
Mutations in ELANE and HAX1 lead to elevated ROS levels and diminished hematopoietic differentiation potential in an human induced pluripotent stem cell model of severe congenital neutropenia
P.A. Olofsen, P. Maczuga, P.M.H. van Strien, I.P. Touw
Selective mRNA translation controls erythropoiesis: regulation and function of the RNA-binding protein Csde1
Kat Moore, Rastislav Horos, Carmen van der Zwaan, Sander Meijer, Peter-Bram 't Hoen, Marieke von Lindern
Increased formation and increased degradation of fibrin clots in solvent-detergent plasma: a 72 hour observation study between Omniplasma and Quarantine plasma
Joyce J.B.C. van Beers, Lieve T. van Egmond, Rick J.H. Wetzels, Erik A. M. Beckers, René van Oerle, Ron J.M.H.E. Straat, Yvonne M.C. Henskens
Influence of INR level on the agreement between capillary and venous INR results
Joseph S. Biedermann, Frank W.G. Leebeek, Peter N. Buhre, Sacha de Lathouder, Jan P.F. Barends, Moniek P.M. de Maat, Felix J.M. van der Meer, Marieke J.H.A. Kruip
Population pharmacokinetics in Hemophilia A: Towards individualization of perioperative replacement therapy
H.C.A.M. Hazendonk, J. Lock, K. Fijnvandraat, F.J.M. van der Meer, K. Meijer, B.A.P. Laros-van Gorkom, M. Driessens, F.W.G. Leebeek, R.A.A. Mathôt, M.H. Cnossen
Overdosing of replacement therapy in perioperative von Willebrand patients: a need for patient-tailored therapy
H.C. Veerman, H.C.A.M. Hazendonk, Y.V. Sanders, F.W.G. Leebeek, M.H. Cnossen
Combining lenalidomide and cyclophosphamide is synergistic and has clear immune-modulating effects in lenalidomide refractory patients
L. E. Franssen, Inger S. Nijhof, S. Zweegman, Mark-David Levin, Harry R. Koene, A. Beeker, A. C. Bloem, G. M.J. Bos, L. M. Faber, S. K. Klein, E. J.F.M. de Kruijf, E. van der Spek, S. Wittebol, J. van Velzen, B. van Kessel, T. Mutis, P. Sonneveld, H. M. Lokhorst, Niels W.C.J. van de Donk
Modulation of CD38 expression levels on multiple myeloma cells by all-trans retinoic acid improves the efficacy of the anti-CD38 monoclonal antibody daratumumab
Inger S. Nijhof, Henk M. Lokhorst, Berris van Kessel, Richard W.J. Groen, Anton C. Martens, Willy A. Noort, Regina de Jong-Korlaar, Parul Doshi, Saskia K. Klein, Tuna Mutis, Kate Sasser, Niels W.C.J. van de Donk
Anaemia in general practice: causes and survival
Karlijn Stouten, Jurgen A. Riedl, Pieter Sonneveld, Mark David Levin
Characterisation of reticulocyte differentiation: from in vivo to in vitro
Elina Ovchynnikova, Marea van der Rijst, Emile van den Akker, Marieke von Lindern
Complement activation in AIHA as footprint for difficult-to-detect IgM-autoantibodies
Elisabeth Meulenbroek, Conny Brouwer, Claudia Folman, Masja de Haas, Rien van Oers, Sacha Zeerleder, Diana Wouters
Increased risk of development of malignancies in adult patients treated with antithymocyte globulin as first line treatment for acquired aplastic anaemia
Joost GK van der Hem, Liesbeth C de Wreede, Anneke Brand, Hendrik Veelken, Fred Falkenburg, Constantijn JM Halkes
An alternative ITGB2 splice variant encodes a novel hematopoietic restricted minor histocompatibility antigen with therapeutic relevance
Margot J. Pont, Dyantha I. van der Lee, Edith D. van der Meijden, Cornelis A.M. van Bergen, M. Willy Honders, Matthias Eefting, Peter-Bram A. 't Hoen, J.H. Frederik Falkenburg, Marieke Griffioen
Inhibition of Akt-signalling promotes the generation of superior tumour-reactive T cells for adoptive immunotherapy
Anniek B van der Waart, Noortje MP van de Weem, Frans Maas, Cynthia SM Kramer, Michel GD Kester, JH Frederik Falkenburg, Nicolaas Schaap, Joop H Jansen, Robbert van der Voort, Luca Gattinoni, Willemijn Hobo, Harry Dolstra
In vitro generation of HLA-DP-restricted donor T cells with hematopoiesis specificity
Aicha Laghmouchi, Conny Hoogstraten, J.H. Frederik Falkenburg, Inge Jedema
T-cell receptors (TCRs) specific for the intracellular transcription factor Bob1 allow efficient targeting of human B-cell leukemia and multiple myeloma
Lorenz Jahn, Pleun Hombrink, Renate S. Hagedoorn, Dirk M. van der Steen, Michel G.D. Kester, Chopie Hassan, Marjolein P. Schoonakker, Erwin P. van der Pijl, Peter A. van Veelen, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk

Abstracts van het 9e Dutch Hematology congress 2015

Ex vivo generation of human plasmacytoid and myeloid dendritic cell-based vaccines from CD34+ hematopoietic progenitor cells
Soley Thordardottir, Basav N. Hangalapura, Tim Hutten, Marta Cossu, Jan Spanholtz, Nicolaas Schaap, Timothy Radstake, Robbert van der Voort, Willemijn Hobo, Harry Dolstra
Vitiligo after allogeneic stem cell transplantation associated with the presence of donor CD4 T-cells recognizing a melanocyte specific MiHA
P. van Balen, E.G.A. Lurvink, M. van de Meent, M.W. Honders, J.J. Out-Luiting, N.A. Gruis, J.H.F. Falkenburg, M. Griffioen
High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations
Davide Monteferrario, Sylvie M Noordermeer, Saskia Bergevoet, Gerwin Huls, Joop H Jansen, Bert A van der Reijden
Phosphoproteomics of a panel of AML cell lines reveals oncogenic signaling and candidate drivers
Carolien van Alphen, Jacqueline Cloos, Sander R. Piersma, Jaco C. Knol, Thang V. Pham, Gert J. Ossenkoppele, Henk Verheul, Connie R. Jimenez, Jeroen J.W.M. Janssen
Clonal analysis of human hematopoiesis by cellular barcoding
Mirjam Belderbos, Gerald de Haan, Taco Koster, Leonid Bystrykh
Potent human graft versus acute leukemia responses are mediated by cytotoxic antibodies
Marijn Gillissen, Etsuko Yasuda, Sophie Levie, Arjen Bakker, Martijn Kedde, Yvonne Claassen, Cynthia Huisman, Tim Beaumont, Pauline van Helden, Hergen Spits, Mette Hazenberg
Massive parallel sequencing of full-length B-cell receptor sequences reveals HLA-dependent shaping of the B-cell immune repertoire
Marvyn T. Koning, Sander A.J. van der Zeeuw, Marcelo Navarrete, Cornelis A.M. van Bergen, Valeri Nteleah, Marieke Griffioen, Szymon M. Kielbasa, Hendrik Veelken
Dendritic cell subsets in myelodysplastic syndromes
N Kerkhoff, T.M. Westers, H.J. Bontkes, R. Mebius, S. Kordasti, G.J. Mufti, T.D. de Gruijl, A.A. van de Loosdrecht
Essential role for non-canonical PRC1.1 in leukemia independent of the canonical PRC2/PRC1 axis
Henny Maat, Vincent van den Boom, Marjan Geugien, Ana Sotoca, Jenny Jaques, Annet Brouwers-Vos, Fabrizia Fusetti, Henk Stunnenberg, Edo Vellenga, Joost Martens, Jan Jacob Schuringa
Loss of ASXL1 triggers an apoptotic response in human hematopoietic stem and progenitor cells
Susan Hilgendorf, Hendrik Folkerts, Jan-Jacob Schuringa, Edo Vellenga
Tumor suppressor genes and cooperate in leukemia development and glucocorticoid therapy resistance
Esther Tijchon, Rene Marke, Dorette van Ingen Schenau, Judith M Boer, Marc Demkes, Liesbeth van Emst, Laurens T van der Meer, Roland P Kuiper, Peter M Hoogerbrugge, Monique L den Boer, Frank N van Leeuwen, Blanca Scheijen
miRNA-125a expands multilineage long-term repopulating activity to hematopoietic stem cells and multipotent progenitors
Edyta E Wojtowicz, Peter van Veelen, Mathilde JC Broekhuis, Hans WJ de Looper, Ellen Weersing, Martha Ritsema, Farshid M Alemdehy, Stefan J Erkeland, Leonid V Bystrykh, Gerald de Haan

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